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ORIGINAL ARTICLE
Year : 2014  |  Volume : 16  |  Issue : 2  |  Page : 67-69

Interventional non-RCT study on the efficacy of Mupirocin versus Neomycin in the eradication of nasal carriers of Staphylococcus aureus in theatre staff


1 Department of General Surgery, Government Medical College, Thiruvananthapuram, Kerala, India
2 Department of Microbiology, Government Medical College, Thiruvananthapuram, Kerala, India

Correspondence Address:
Geetha Raveendran
Department of Microbiology, Government Medical College, Thiruvananthapuram, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0972-1282.144713

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Aim: Nasal carriage of Staphylococcus aureus plays a pivotal role in the spread of nosocomial infections even in tertiary care centers. We decided to detect nasal carriage of S. aureus in our institution and eradicate it with local application of Mupirocin/Neomycin and to compare their efficiency. Materials and Methods: The study was conducted over a period of 12 months among 50 surgical theatre staff. In all, two nasal swabs were taken from each person at an interval of one week. Alternate nasal carriers identified were given Mupirocin/Neomycin for application in the anterior nares. A third swab was taken seven days after treatment. Observations and Result: Out of the fifty persons, 16 tested positive for S. aureus (32%). Out of the 16, two were Methicillin resistant Staphylococcus aureus (MRSA). All repeat swabs were negative after treatment with Mupirocin. However, 4% were not cured after treatment with Neomycin. Since the sample size is too small, an elaborate study should be conducted to include theatre staff of all speciality and this can confirm the promising role of Neomycin, as the percentage of resistance in this study appears negligible.


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