Citation Information :
Sivaradjy M, Rajkumari N. Role of gene sequencing in the diagnosis, tracking and prevention of parasitic diseases – A brief review. J Acad Clin Microbiol 2022; 24 (S1):32-35.
Parasitic infections and its burden are increasing worldwide and there are many unknown areas among the parasites for a long time which makes the eradication of most of the parasites impossible till now. The mechanism of how certain parasites evade human immune response and how they escape from the action of antiparasitic drugs were unclear. It is also difficult to maintain their culture in the laboratory which makes it difficult to identify to the species level most of the time. The field of sequencing has undergone many advances recently. The availability of entire genome sequences has revolutionised the study of infectious organisms, including parasites. It helps us to know the complete nucleotide sequence of even a complex genome at larger number. In the form of pilot genome sequencing studies, genomics approaches have been used to deal with the problem of tropical neglected parasitic illnesses for more than 20 years. In this, new technology like sequencing is coming up in a big way not only in the diagnosis but also targeted therapeutics and its control. Hence, different sequencing methods have been explored briefly in its role in parasitic diseases.
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