Citation Information :
Joy S, Philip NS, John NS. Improved patient outcome in Listeria monocytogenes meningitis through molecular syndromic panel test. 2023; 25 (2):61-63.
This case report emphasises the significance of early diagnosis and treatment of Listeria monocytogenes infections as it can cause significant morbidity and mortality. Due to the limited/delayed diagnostic sensitivity of blood and cerebrospinal fluid (CSF) cultures, the diagnosis of Listeria meningitis is challenging. Here, we report the case of a 48-year-old male patient with multiple myeloma presented with fever, vomiting and headache. Routine investigations revealed hypocalcemia, elevated C-reactive protein and hypokalaemia. Despite being treated with ceftriaxone empirically, the patient's condition did not improve. Molecular testing of the CSF by the FilmArray meningitis/encephalitis panel identified L. monocytogenes within two hours. Ampicillin and Gentamicin were administered immediately and symptoms of the patient improved significantly. This case highlights the use of molecular syndromic panel like the FilmArray, which is highly sensitive for the diagnosis of central nervous system infections and enables targeted therapy and improved outcomes.
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