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VOLUME 24 , ISSUE S1 ( December, 2022 ) > List of Articles

REVIEW ARTICLE

Role of gene sequencing for the diagnosis, tracking and prevention of bacterial infections

Renu Kumari, Benu Dhawan

Keywords : Bacterial infection, diagnosis, gene sequencing, prevention, tracking

Citation Information : Kumari R, Dhawan B. Role of gene sequencing for the diagnosis, tracking and prevention of bacterial infections. 2022; 24 (S1):8-14.

DOI: 10.4103/jacm.jacm_22_22

License: CC BY-NC 4.0

Published Online: 11-11-2022

Copyright Statement:  Copyright © 2022; Wolters Kluwer India Pvt. Ltd.


Abstract

Gene sequencing is the inevitable future of diagnostic microbiology. Of the various molecular assays available, sequencing is the promising technique for detecting culture-negative infections due to uncultivable bacteria namely culture-negative endocarditis, meningitis, brain abscess, keratitis, urinary tract infections, empyema, septic arthritis and septicaemia. Sequencing also helps to predict full resistance profile of bacteria and its virulence traits. Sequencing is an emerging and powerful technique to perform the epidemiological studies in an outbreak situation. This review focuses on the common applications of sequencing in clinical bacteriology including isolate characterisation, antimicrobial resistance and virulence factor profiling, establishing the source of infections and tracking the disease transmission.

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