Journal of The Academy of Clinical Microbiologists

Register      Login

VOLUME 24 , ISSUE 1 ( January-June, 2022 ) > List of Articles

CASE REPORT

Aggregatibacter aphrophilus, a HACEK group pathogen as a cause of prosthetic valve endocarditis

Jyothi Embekkat Kaviyil, Dinoop Korol Ponnambath, Bijulal Sasidharan, Pravi Vidyadharan, Kavita Raja

Keywords : 16s rRNA sequencing, Aggregatibacter aphrophilus, HACEK group, infective endocarditis, prosthetic valve endocarditis

Citation Information : Kaviyil JE, Ponnambath DK, Sasidharan B, Vidyadharan P, Raja K. Aggregatibacter aphrophilus, a HACEK group pathogen as a cause of prosthetic valve endocarditis. 2022; 24 (1):41-43.

DOI: 10.4103/jacm.jacm_8_22

License: CC BY-NC 4.0

Published Online: 11-07-2022

Copyright Statement:  Copyright © 2022; Wolters Kluwer India Pvt. Ltd.


Abstract

Prosthetic valve endocarditis (PVE) is one of the most severe forms of infective endocarditis. Here, we describe a case of PVE caused by Aggregatibacter aphrophilus, a member of the HACEK group of pathogens, which is a difficult pathogen to identify using conventional methods. The pathogen was identified by 16s rRNA Sanger sequencing using eight-channel capillary electrophoresis method.


PDF Share
  1. Chirillo F. New approach to managing infective endocarditis. Trends Cardiovasc Med 2021;31:277-86.
  2. Murdoch DR, Corey GR, Hoen B, Miró JM, Fowler VG Jr., Bayer AS, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: The international collaboration on endocarditis-prospective cohort study. Arch Intern Med 2009;169:463-73.
  3. Wang A, Athan E, Pappas PA, Fowler VG Jr., Olaison L, Paré C, et al. Contemporary clinical profile and outcome of prosthetic valve endocarditis. JAMA 2007;297:1354-61.
  4. Khalil H, Soufi S. Prosthetic Valve Endocarditis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK567731/. [Last updated on 2022 Jan 19].
  5. Gupta A, Gupta A, Kaul U, Varma A. Infective endocarditis in an Indian setup: Are we entering the ‘modern’ era?. Indian J Crit Care Med 2013;17:140-7.
  6. Biswa P, Doble M. Production of acylated homoserine lactone by a novel marine strain of proteus vulgaris and inhibition of its swarming by phytochemicals. Microbiol (Reading) 2014;160:2170-7.
  7. Arora N, Panda PK, Cr P, Uppal L, Saroch A, Angrup A, et al. Changing spectrum of infective endocarditis in India: An 11-year experience from an academic hospital in North India. Indian Heart J 2021;73:711-7.
  8. Choi HN, Park KH, Park S, Kim JM, Kang HJ, Park JH, et al. Prosthetic valve endocarditis caused by HACEK organisms: A case reports and systematic review of the literature. Infect Chemother 2017;49:282-5.
  9. Bläckberg A, Morenius C, Olaison L, Berge A, Rasmussen M. Infective endocarditis caused by HACEK group bacteria-a registry-based comparative study. Eur J Clin Microbiol Infect Dis 2021;40:1919-24.
  10. Chambers ST, Murdoch D, Morris A, Holland D, Pappas P, Almela M, et al. HACEK infective endocarditis: Characteristics and outcomes from a large, multi-national cohort. PLoS One 2013;8:e63181.
  11. El-Dalati S, Cinti S, Owczarczyk A, Riddell J, Fagan C, Chanderraj R, et al. The clinical impact of 16S rRNA bacterial sequencing in infective endocarditis. Open Forum Infect Dis 2019;6:PS92.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.