Citation Information :
Suneetha V, Babu M, Manjunatha M. Endogenous endophthalmitis caused by Aspergillus flavus in an immunocompetent individual – A rare case with review of literature. 2019; 21 (1):34-37.
There are very few reports of Aspergillus flavus causing endogenous Aspergillus endophthalmitis (EAE) in immunocompetent individuals although it is well recognized in the immunocompromised. Treatment can be with intravitreal, intravenous and oral antifungal agents. We present a case of EAE in a 23-year-old female with no predisposing risk factors. A detailed systemic evaluation failed to reveal any systemic focus or predisposing factor for fungal infection. The patient had received an intravenous dextrose infusion two days before this episode while being treated at a rural hospital for fever. She presented with a sudden loss of vision and was subsequently managed with intravitreal voriconazole therapy. This case adds to the limited literature on the prevalence of endogenous endophthalmitis in immunocompetent patients and supports the use of voriconazole in such cases.
Ramakrishnan R, Bharathi MJ, Shivkumar C, Mittal S, Meenakshi R, Khadeer MA, et al. Microbiological profile of culture-proven cases of exogenous and endogenous endophthalmitis: A 10-year retrospective study. Eye (Lond) 2009;23:945-56.
Connell PP, O'Neill EC, Fabinyi D, Islam FM, Buttery R, McCombe M, et al. Endogenous endophthalmitis: 10-year experience at a tertiary referral centre. Eye (Lond) 2011;25:66-72.
Essman TF, Flynn HW Jr., Smiddy WE, Brod RD, Murray TG, Davis JL, et al. Treatment outcomes in a 10-year study of endogenous fungal endophthalmitis. Ophthalmic Surg Lasers 1997;28:185-94.
Hosseini H, Saki S, Saki N, Eghtedari M. Aspergillus endophthalmitis in orthotopic liver transplantation. Indian J Med Sci 2009;63:253-6.
Panigrahi PK, Roy R, Pal SS, Mukherjee A, Lobo A. Aspergillus terreus endogenous endophthalmitis: Report of a case and review of literature. Indian J Ophthalmol 2014;62:887-9.
Rana M, Fahad B, Abid Q. Embolic Aspergillus endophthalmitis in an immunocompetent patient from aortic root Aspergillus endocarditis. Mycoses 2008;51:352-3.
Sachdev N, Gupta P, Singh R, Chakrabarti A, Gupta V, Gupta A, et al. Bilateral simultaneous endogenous Aspergillus endophthalmitis in an immunocompetent patient. Retin Cases Brief Rep 2010;4:14-7.
Gupta P, Sachdev N, Kaur J, Dey P, Gupta V, Gupta A, et al. Endogenous mycotic endophthalmitis in an immunocompetent patient. Int Ophthalmol 2009;29:315-8.
Riddell J 4th, Comer GM, Kauffman CA. Treatment of endogenous fungal endophthalmitis: Focus on new antifungal agents. Clin Infect Dis 2011;52:648-53.
Sadiq MA, Hassan M, Agarwal A, Sarwar S, Toufeeq S, Soliman MK, et al. Endogenous endophthalmitis: Diagnosis, management, and prognosis. J Ophthalmic Inflamm Infect 2015;5:32.
