Journal of The Academy of Clinical Microbiologists

Register      Login

VOLUME 18 , ISSUE 2 ( July-December, 2016 ) > List of Articles

CASE REPORT

Methicillin-resistant staphylococci presenting as rare hospital-acquired infections: A case series

Sheeba K Thomas, Shoba Kurian Pulikottil, Dani K Thampi, Netto Jacob

Keywords : Meningitis, Methicillin-resistant coagulase-negative staphylococci, Methicillin-resistant Staphylococcus aureus, valve leaflet vegetation

Citation Information : Thomas SK, Pulikottil SK, Thampi DK, Jacob N. Methicillin-resistant staphylococci presenting as rare hospital-acquired infections: A case series. 2016; 18 (2):117-120.

DOI: 10.4103/0972-1282.194944

License: CC BY-NC 4.0

Published Online: 17-08-2024

Copyright Statement:  Copyright © 2016; Wolters Kluwer India Pvt. Ltd.


Abstract

Even though Staphylococcus aureus is present as normal flora on the skin, it is a pathogen when present in otherwise normally sterile body fluids such as cerebrospinal fluid and blood. Methicillin-resistant S. aureus (MRSA), presumed to originate from a patient or carrier, is responsible for both community-acquired as well as hospital-acquired infections (HAIs). Coagulase-negative staphylococci (CoNS) are present as normal flora on skin but cause vegetations on valve leaflets in subacute bacterial endocarditis and surgical site infection. MRCoNS arises from the skin flora of hospitalised patients and can contribute to similar infections in the hospital setting. We present three cases of Methicillin-resistant staphylococci causing HAI, MRSA causing meningitis with obstructive hydrocephalus, MRCoNS causing bacteraemia in a child with congenital cyanotic heart disease and MRCoNS causing surgical site infection on an amputation stump.


PDF Share
  1. Peacock SJ. Staphylococcus. Topley and Wilson's Microbiology and Microbial Infections. Bacteriology. 10 th ed. John Wiley & Sons, Inc.; 2005. p. 771-832.
  2. Michael AG. Is methicillin resistant Staphylococcus aureus an emerging community pathogen? A review of the literature. Can J Infect Dis Microbiol 2000;11:202-11.
  3. Hafsat AG, Yakub AG, Galadima BG, James AA, Abubakar S. Methicillin resistant Staphylococcus aureus: A review. Adv Anim Vet Sci 2015;3:79-98.
  4. Musser JM, Kapur V. Clonal analysis of methicillin-resistant Staphylococcus aureus strains from intercontinental sources: Association of the mec gene with divergent phylogenetic lineages implies dissemination by horizontal transfer and recombination. J Clin Microbiol 1992;30:2058-63.
  5. Archer GL, Niemeyer DM, Thanassi JA, Pucci MJ. Dissemination among staphylococci of DNA sequences associated with methicillin resistance. Antimicrob Agents Chemother 1994;38:447-54.
  6. Hanssen AM, Kjeldsen G, Sollid JU. Local variants of staphylococcal cassette chromosome mec in sporadic methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci: Evidence of horizontal gene transfer? Antimicrob Agents Chemother 2004;48:285-96.
  7. Wu S, Piscitelli C, de Lencastre H, Tomasz A. Tracking the evolutionary origin of the methicillin resistance gene: Cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri. Microb Drug Resist 1996;2:435-41.
  8. Couto I, de Lencastre H, Severina E, Kloos W, Webster JA, Hubner RJ, et al. Ubiquitous presence of a mecA homologue in natural isolates of Staphylococcus sciuri. Microb Drug Resist 1996;2:377-91.
  9. Piras G, Raze D, el Kharroubi A, Hastir D, Englebert S, Coyette J, et al. Cloning and sequencing of the low-affinity penicillin-binding protein 3r-encoding gene of Enterococcus hirae S185: Modular design and structural organization of the protein. J Bacteriol 1993;175:2844-52.
  10. Shane AL, Hansen NI, Stoll BJ, Bell EF, Sánchez PJ, Shankaran S, et al. Methicillin-resistant and susceptible Staphylococcus aureus bacteremia and meningitis in preterm infants. Pediatrics 2012;129:e914-22.
  11. Dylewski J, Martel G. A case of spontaneous methicillin-resistant Staphylococcus aureus meningitis in a health care worker. Can J Infect Dis Med Microbiol 2004;15:336-8.
  12. Huebner J, Donald AG. Native valve endocarditis due to coagulase negative staphylococci. Annu Rev Med 1999;50:223-36.
  13. Rupp ME, Archer GL. Coagulase-negative staphylococci: Pathogens associated with medical progress. Clin Infect Dis 1994;19:231-43.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.