Aspergillosis is one of the most common fungal infections in humans caused by Aspergillus species. However, not all Aspergillus species possess the same antifungal susceptibility patterns. Aspergillus terreus is an emerging pathogen which commonly occurs in infections of immunocompromised individuals and is associated with high mortality. It gains its importance in being mostly resistant to treatment with amphotericin B. The four cases of A. terreus reported here highlight the fact that fungal infections caused by this species are on the rise. Early diagnosis and prompt treatment are important to prevent an unfavorable outcome. The optimal therapy for infections caused by this emerging pathogen is still to be ascertained.
Marr KA, Carter RA, Crippa F, Wald A, Corey L. Epidemiology and outcome of mould infections in haematopoetic stem cell transplant recipients. Clin Infect Dis 2002;34:909-17.
Cookie FJ, Terpos E, Boyle J, Rahemtulla A, Rogers TR. Disseminated Aspergillus terreus infection arising from cutaneous inoculation treated with caspofungin. Clin Microbiol Infect 2003;9:1238-41.
CLSI (2008b) Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; Approved standard CLSI document M38-A2. Clinical and Laboratory Standards Institute, Wayne.
Steinbach WJ, Perfect JR, Schell WA, Walsh TJ, Benjamin DK. In vitro analysis, animal models and 60 clinical cases of invasive Aspergillus terreus infection. Antimicrob Agents Chemother 2004;48:3217-25.
Nannini EC, Paphitou NI, Ostrosky-Zeichner L. Peritonitis due to Aspergillus and zygomycetes in patients undergoing peritoneal dialysis: Report of 2 cases and review of the literature. Diagn Microbiol Infect Dis 2003;46:49-54.
Steinbach WJ, Benjamin DK Jr, Kontoyiannis DP, Perfect JR, Lutsar I, Marr KA, et al. Infections due to Aspergillus terreus: A multicenter retrospective analysis of 83 cases. Clin Infect Dis 2004;39:192-8.
Sutton, DA, Sanche SE, Revankar SG, Fothergill AW, Rinaldi MG. In vitro Amphotericin B resistance in clinical isolates of Aspergillus terreus, with a head-to-head comparison to voriconazole. J Clin Microbiol 1999;37:2343-5.
Varughese S, Mathews MS, Tamilarasi V. Successful renal transplantation following treatment of Aspergillus terreus peritonitis in a continuous ambulatory peritoneal dialysis patient. Indian J Nephrol 2011;21:208-11.
Ozer B, Kalaci A, Duran N, Dogramaci Y, Yanat AN. Cutaneous infection caused by Aspergillus terreus. J Med Microbiol 2009;58:968-70.
Akhaddar A, Gazzaz M, Albouzidi A, Lmimouni B, Elmostarchid B, Boucetta M. Invasive Aspergillus terreus sinusitis with orbitocranial extension: Case report. Surg Neurol 2008;69:490-5.
Stevens DA, Kan VL, Judson MA, Morrison VA, Dummer SD, Denning DW, et al. Practice guidelines for disease caused by Aspergillus. Infectious Diseases Society of America. Clin Infect Dis 2000;30:696-709.
Baddley JW, Pappas PG, Smith AC, Moser SA. Epidemiology of Aspergillus terreus at a University hospital. J Clin Microbial 2003;41:5525-9.
