• Users Online: 320
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 20  |  Issue : 1  |  Page : 14-18

The emergence of Mupirocin resistance among the clinical isolates of Staphylococci in a rural tertiary health-care centre of South India


Department of Microbiology, AIMS, B.G. Nagar, Karnataka, India

Correspondence Address:
Dr. Vijaya Shivanna
Department of Microbiology, AIMS, B.G. Nagar - 571 448, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jacm.jacm_18_17

Rights and Permissions

INTRODUCTION: Mupirocin is mainly used for decolonisation of Methicillin-resistant Staphylococcus aureus among patients and health-care workers. However resistance originates from coagulase negative staphylococci (CoNS) and spreads to S. aureus by horizontal gene transfer. Hence, the present study was done to determine the overall prevalence of high- and low-level Mupirocin resistance among S. aureus and CoNS and correlate with the occurrence of Methicillin and inducible Clindamycin resistance. MATERIALS AND METHODS: A total of 100 consecutive, non-repetitive, clinical isolates of Staphylococci were obtained from various samples in a rural tertiary care hospital of Karnataka between August and September 2016. Antibiotic susceptibility testing was done according to the Clinical and Laboratory Standards Institute (M100-S25, 2015) guidelines. Low- and high-level Mupirocin resistance was screened using 5 μg and 200 μg discs, respectively. RESULTS: Of 100 staphylococcal isolates, high-level Mupirocin resistance (MupRH) was detected in 13 isolates and low-level Mupirocin resistance (MupRL) was found in 4 isolates. Of 13 HLMR isolates, majority were CoNS (12 out of 13, 92.31%). Even in LLMR isolates, 75% (3 out of 4) were CoNS. All the HLMR and LLMR isolates were Methicillin resistant (P < 0.05). CONCLUSION: High prevalence of Mupirocin resistance was found in the present study. Hence, screening for Mupirocin resistance should be routinely done and the drug must be used judiciously.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed298    
    Printed26    
    Emailed0    
    PDF Downloaded17    
    Comments [Add]    

Recommend this journal